HEALTH AND DISEASE STATUS IN THE BLSA--THE PROSTATE GLAND

在过去的一年里，已经完成了两项研究。第一个有更多的 描述了良性前列腺增生症在BLSA男性中的分布。发生以下情况的概率 随着年龄的增长和年龄的增加，BPH的最终手术量增加 出现前列腺肥大和梗阻症状。《时代》 临床诊断的BPH的具体患病率与年龄密切相关- 病理明确的良性前列腺增生症的特殊尸检盛行率。 第二项研究检测了前列腺特异性抗原作为前列腺癌的标志。 癌症。纵向分析显示，年龄调整后的比率显著 前列腺癌患者、良性前列腺增生症患者和对照组之间PSA的变化。 在前列腺增生症和前列腺癌患者之间PSA没有差异的时候 (确诊前5年)，PSA的变化率明显更大 前列腺癌的受试者。研究结果表明，这种变化的速度 在PSA中可能是一种敏感而特异的早期标志物 前列腺癌。

In the past year two studies have been completed. The first has further characterized the distribution of BPH in the BLSA men. The probability of eventual surgery for BPH increases with increasing age and with the presence of an enlarged prostate and obstructive symptoms. The age specific prevalence of clinically diagnosed BPH agree closely with the age- specific autopsy prevalency of pathologically defined BPH. A second study examined prostate specific antigen as a marker of prostatic cancer. Longitudinal analyses demonstrated a significant age adjusted rate of change in PSA between subjects with prostate cancer, BPH and controls. At a time when PSA did not differ between BPH and prostate cancer subjects (5 years before diagnosis), rate of change in PSA was significantly greater in subjects with prostate cancer. The findings suggest that rate of change in PSA may be a sensitive and specific early marker for the development of prostate cancer.