RADIOLOGICAL DIAGNOSTIC ONCOLOGY GROUP 11

此应用程序响应RFA 86-CA-10，National 协作成像跟踪项目。我们组织了一个小组 成立放射诊断肿瘤学小组 (RDOG)。 协作小组将被设计为提供一种手段 由此，可以对疗效研究和诊断成像测试 以一种及时的方式建立，并据此分析数据 准确的方式。在运营中心的赞助下 和统计和数据管理小组，我们将建立一个 持续运行的机制：全面优化图像质量 参与站点；跨多个站点获取一致完整的数据 参与站点；创建图像库以允许衍生 在随后的几年中进行研究；并为临床分析成像数据 有效性和潜在的算法开发使用 适当的分析技术。所采用的技术 分析将是最先进的，涉及接收器操作 特性曲线分析；将特别注意确保 对一些可能会排除准确性的偏差进行修正 数据分析。 该应用程序解决了肺癌和前列腺癌的分期问题 癌症。X线平片、CT和MRI的绝对值 非小细胞肺癌的分期 癌症将被确定；MRI的增量价值超过 CT也将被评估。用于前列腺癌的分期 MRI和经直肠超声检查的准确性将在#年确定 既有绝对的方式，也有渐进的方式。

This application is in response to RFA 86-CA-10, National Collaborative Imaging Trails Project. We have organized a group of institutions to form the Radiologic Diagnostic Oncology Group (RDOG). The collaborative group will be designed to provide a means whereby efficacy studies on and diagnostic imaging tests can be instituted in a timely fashion and whereby data can be analyzed in a accurate manner. Under the auspices of an operations center and statistical and data management group, we will establish an ongoing mechanism to: optimize image quality across all participating sites; obtain consistent and complete data across participating sites; create an imaging library to allow derivative studies in subsequent years; and analyze imaging data for clinical effectiveness and potential algorithm development using appropriate analytic techniques. The techniques employed for analysis will be state-of-the-art involving receiver operating characteristic curve analysis; special care will be taken to ensure correction for a number of biases that might preclude accurate data analyses. The application addresses the staging of both lung and prostate cancer. The absolute value of plain radiographs, CT, and MRI in the staging of patients with non-small-cell bronchogenic carcinoma will be determined; the incremental value of MRI over CT will also be assessed. For staging prostate cancer the accuracy of MRI and transrectal sonography will be determined in both absolute and incremental ways.