SPECIALIZED CENTER OF RESEARCH IN ARTERIOSCLEROSIS

这项提案是为了延长A/S特别报告的一个组成部分 心血管研究所的跨学科项目 加州大学旧金山分校，位于13号 Moffitt/Long医院和医学大楼楼层。 计划继续并扩大目前的方案 脂蛋白及其与动脉粥样硬化形成关系的研究， 利用分子和细胞生物学、免疫学、 大分子生物化学和数学生物学。重点 贯穿始终的将是结构、合成、分泌、 与细胞的相互作用和血浆脂蛋白的分解代谢 实验动物和模型系统。该计划还包括 脂蛋白与胆固醇代谢的临床研究 在高脂蛋白血症和血脂异常血症中， 新的遗传性脂蛋白紊乱和研究将发展更多 治疗高脂血症的有效手段，尤其是高脂血症 杂合性家族性高胆固醇血症 通络通络法对脂类储存和动脉粥样硬化的影响 损伤。 整个计划包括一个核心血脂诊所、核心实验室 和行政支持设施，以及八个个人 项目： A-1：肝脏在脂蛋白分解代谢中的作用。 A-2：卵磷脂：胆固醇的构效关系 酰基转移酶和胆固醇酯转移蛋白。 A-3：脂蛋白间胆固醇酯转移的调节 物种。 A-4：脂蛋白的结构。 A-5：新生血浆脂蛋白在肝脏中的亚细胞起源。 B-1：遗传性骨肉瘤的特征和发病机制 高脂蛋白血症和高脂蛋白血症及其临床意义 与动脉粥样硬化性疾病的关系。 B-2：血浆脂蛋白水平正常化对 脂蛋白和甾醇代谢与动脉粥样硬化和 杂合性家族性高胆固醇血症中的黄色瘤皮损。 B-3：非胰岛素依赖型患者的血浆脂蛋白代谢 糖尿病、终末期肾病和家族性疾病 高胆固醇血症及其与文献记载的关系 动脉硬化。

This proposal is for renewal of the A/S SCOR, a component interdisciplinary program of the Cardiovascular Research Institute of the University of California, San Francisco, located on the 13th floor of Moffitt/Long Hospital and the Medical Sciences Building. It is planned to continue and broaden the current program of research on lipoproteins and their relation to atherogenesis, utilizing methods of molecular and cell biology, immunology, macromolecular biochemistry, and mathematical biology. Emphasis throughout will be p)aced on the structure, synthesis, secretion, interaction with cells, and catabolism of plasma lipoproteins in experimental animals and model systems. The program also includes clinical investigations of lipoprotein and cholesterol metabolism in hyperlipoproteinemia and dyslipoproteinemia, the elucidation of new genetic lipoprotein disorders and research to develop more effective means to treat hyperlipoproteinemia, especially that of heterozygous familial hypercholesterolemia, and to determine the effect of this therapy upon lipid storage and atherosclerotic lesions. The total program includes a core lipid clinic, core laboratories and administrative support facilities, and eight individual projects: A-1: Role of liver in lipoprotein catabolism. A-2: Structure-function relationships of lecithin:cholesterol acyltransferase and cholesteryl ester transfer proteins. A-3: Regulation of cholesteryl ester transfer between lipoprotein species. A-4: Structure of lipoproteins. A-5: Subcellular origins of nascent plasma lipoproteins in liver. B-1: Characterization and pathogenesis of genetic hyperlipoproteinemias and dysbetalipoproteinemias and their relationship to atherosclerotic disease. B-2: Effect of normalization of plasma lipoprotein levels on lipoprotein and sterol metabolism and on atherosclerotic and xanthomatous lesions in heterozygous familial hypercholesterolemia. B-3: Plasma lipoprotein metabolism in non-insulin dependent diabetes, end-stage renal disease and familial hypercholesterolemia, and its relationship to documented atherosclerosis.