Deciphering IFN type III, TGFβ, IL-10 and adenosine pathways in natural killer cells: enhancing the innate anti-metastatic response against breast cancer progression

这个项目将确定一个或多个因素是否在肿瘤中产生。细胞激素和代谢物)抑制NK细胞控制乳腺癌扩散使用最好的小鼠肿瘤模型。我们将利用遗传学特异性地删除NK细胞对这些因子的反应。这是一种全新的方法，这些信息将允许在手术和局部放疗和/或化疗后更合理地设计癌症治疗。

This project will determine whether one or more factors produced in tumours (eg. cell hormones and metabolites) inhibits NK cells from controlling breast cancer spread using the best available mouse tumour models. We will use genetics to specifically delete response to these factors by NK cells. It is a completely novel approach and this information will allow for the more rational design of cancer treatments following surgery and local radiotherapy and/or chemotherapy.