BACTERIAL INTERRELATIONSHIPS IN AN ANIMAL MODEL

1)为了研究体内细菌的相互关系， 动物模型的细菌变形链球菌，乳酸杆菌 干酪和粘性放线菌。 2)为了确定顺序接种的效果， 细菌的定植和随后的龋齿的产生。 3)确定单因素对龋齿产生的影响 和多次接种。 4)为了确定调节宿主反应的效果， 一种或多种细菌的定植和生产 龋齿 5)为了比较体内模型中获得的结果， 在体外实验中获得的那些（克拉克森，R01根 体外龋齿研究）。

1) To study bacterial interrelationships in an in vivo gnotobiotic animal model of the bacteria Streptococcus mutans, Lactobacillus casei and Actinomyces viscosus. 2) To determine the effects of sequential inoculation of the colonization of bacteria and subsequent production of caries. 3) To determine the effect on the production of caries of mono- and of multiple inoculation. 4) To determine the effects of modulation of the host response to one or more of the bacteria on the colonization and production of caries. 5) To compare the results obtained in the in vivo model with those obtained in the in vitro experiment (Clarkson, R01 Root caries study in vitro).