EFFECTS OF METALS AND PROTEINS ON NUCLEIC ACIDS

该项目重点关注与以下相关的分子之间的相互作用 遗传信息转移。 主要目标是确定 在什么条件下金属离子是信息所必需的 转移，以及在什么条件下它们对信息产生影响 以这种方式影响生物老化。 感兴趣的话题 主要有：（1）金属离子对核酸结构的影响 酸、核蛋白和染色质;（2） 铝参与阿尔茨海默病;（3）交联 核酸链的金属离子;（4）的结构， RNA聚合酶活性位点;（5）金属离子与细胞衰老。

This project focuses on the interaction of molecules concerned with genetic information transfer. A primary objective is to determine under what conditions metal ions are essential for information transfer, and under what conditions they impact on the information in such a way as to influence biological aging. Topics of interest are: (1) the effects of metal ions on the structure of nucleic acids, nucleoproteins and chromatin; (2) the mechanism of involvement of aluminum in Alzheimer's disease; (3) crosslinking of nucleic acid strands by metal ions; (4) the structure of the active site of RNA Polymerase; (5) metal ions and cellular aging.