THE MANIPULATION OF IMMUNE PROCESSES WITH HETEROCROSSLINKED ANTIBODIES

1.以抗T3和抗FCR为靶点的人T细胞和K细胞 异种交叉连接的抗肿瘤抗体已被根除 裸鼠体内的人卵巢癌细胞。 2.含抗A抗体的异交联体抗体 与细胞表面抗体相连的可溶性抗原 抗原提呈细胞(APC)上的决定簇，大大增强 抗原呈递的效率。增强了演示文稿 当抗原被靶向Fc受体表面时被看到 免疫球蛋白、MHC I类和MHC II类分子 APC。靶向抗原呈递是抗原特异性的，而且是I-A 有限制。

1. Human T cells and K cells targeted with anti-T3 and anti-FcR, heterocrosslinked to anti-tumor antibodies eradicate established human ovarian cancer cells in nude mice. 2. Heterocrosslinked antibodies containing an antibody against a soluble antigen linked to an antibody against a cell surface determinant on an antigen presenting cell (APC), greatly enhance the efficiency of antigen presentation. Enhance presentation has been seen when antigen was targeted to Fc receptors, surface immunoglobulin, MHC class I and MHC class II molecules on the APC. Targeted antigen presentation is antigen specific and I-A restricted.