SPECIALIZED CENTER OF RESEARCH IN ARTERIOSCLEROSIS

这是HL-14237-10 SCOR的延续申请：动脉炎 中心 计划继续并扩大目前的基本方案， 脂蛋白结构和功能的临床研究， 强调整个结构，合成，分泌，相互作用 实验动物的细胞表面和血浆脂蛋白的催化剂， 模型系统 它还包括对收集的数据的详细分析， 高脂蛋白血症的患病率和详细特征，新研究 遗传和非遗传因素影响的结构和组成 载脂蛋白与家族性高脂血症治疗研究 高β脂蛋白血症及药物治疗对载脂蛋白的影响 混合物. 整个计划包括核心实验室和行政设施， 六个独立研究项目：1）载脂蛋白在脂蛋白中的作用 2）甘油三酯和胆固醇丰富的脂蛋白的相互作用 颗粒与血管表面; 3）脂蛋白的结构， 载脂蛋白; 4）正常和异常血浆的合成和分泌 5）载脂蛋白的遗传和非遗传决定因素 脂蛋白的变异性; 6）家族性高β脂蛋白血症的治疗。

This is a continuation application for HL-14237-10 SCOR: Arteriosclerosis Center. It is planned to continue and extend the present program of fundamental and clinical research on the structure and function of lipoproteins, with emphasis throughout on the structure, synthesis, secretion, interaction with cell surfaces and catabolism of plasma lipoproteins in experimental animals and model systems. It also includes detailed analysis of data collected on the prevalence and detailed characterization of hyperlipoproteinemia, new research on genetic and non-genetic factors affecting the structure and composition of apolipoproteins and research on the treatment of familial hyperbetalipoproteinemia and the effect of drug treatment upon apolipoprotein composition. The total program includes core laboratories and administrative facilities and six individual research projects: 1) Role of apolipoproteins in lipoprotein catabolism; 2) Interactions of triglyceride- and cholesterol-rich lipoprotein particles with the vascular surface; 3) Structure of lipoproteins and apolipoproteins; 4) Synthesis and secretion of normal and abnormal plasma lipoproteins; 5) Genetic and non-genetic determinants of apolipoprotein variability in lipoproteins; 6) Treatment of familial hyperbetalipoproteinemia.