EXPERIMENTAL LEUKEMOGENESIS

这个项目是关于实验性白血病发生的。哈罗德式 白血病发生的细胞学和病毒学机制研究 都被提出了。外周血淋巴细胞内源性C型RNA病毒的表达 我们将分析差异化的各个阶段，并与 白血病的发展。肿瘤和正常淋巴细胞将用于 识别和分析作为转化病毒目标的细胞。病毒 在恶性转化的不同阶段细胞的表达 已经确定了。淋巴细胞分化在骨肉瘤形成中的作用 重组病毒将被确定。后者的遗传结构 药物将被确定，并与其生物效应有关。转型 和非转化的禽流感病毒将被用来确定 Src基因的结构-功能关系。

This Program Project deals with experimental leukemogenesis. Callaborative investigations of cellular and virological mechanisms related to leukemogenesis are proposed. The expression of endogenous Type C RNA viruses by lymphocytes in various stages of differentiation will be analyzed and related to the development of leukemia. Neoplastic and normal lymphocytes will be used to identify and analyze cells that are targets of transforming viruses. Virus expression by cells in different stages of malignant transformation will be ascertained. The contribution of lymphocyte differentiation to the formation of recombinant viruses will be determined. The genetic structure of the latter agents will be determined and related to their biological effects. Transforming and non-transforming avian oncornoaviruses will be used to determine structure-function relations of src genets.