RADIOTELEMETRIC EVALUATION OF INTERPROXIMAL PLAQUE PH

本拨款申请的目的是为 人牙近端间fm-无线电遥测牙斑pH系统的研制 爱荷华州大学。 该系统将用于菌斑pH值评价 在不同的食物消费模式和评价 抗糖酵解口腔冲洗剂。 研究将分三个阶段进行。 第一阶段将包括体外开发和测试一种 fm-无线电遥测噬菌斑pH系统。 一开始，一个最近在商业上 可用的调频发射机将适用于玻璃pH值 微电极 将采取两种办法。 其中第一个 需要一个完全封装的版本，将被设计为保持 在人类志愿者口腔中。 第二种方法将 允许使用目前使用的留置钢丝遥测装置 适于在需要FM遥测时连接FM发射机。 的 遥测封装将在缓冲溶液中进行可靠性评估， 准确性和平均寿命预期。 根据满意 性能，在第二阶段，遥测方法将用于 八名人类志愿者。 将使用菌斑pH值选择志愿者 筛选方法，以假设最大菌斑pH值响应于可发酵的 碳水化合物 每个志愿者将进行八次不同的测试 包括8至24小时的连续牙斑pH测量。 每次会议将被设计为评估一个特定的食物消费 格局 结果将被分析并用于选择食物序列， 减少产酸反应。 第三阶段将在有限的 志愿者数量，以评估各种抗糖酵解口服冲洗液， 其对长期（12小时）菌斑pH反应的影响。 这种调频无线电遥测方法的发展提供了一个重要的 改进评价粮食消费模式的方法 通过使用人体邻间牙菌斑pH值测量。 将 用于帮助制定新的建议和方法， 预防龋齿。

The purpose of this grant application is to obtain support for the development of a human interproximal fm-radiotelemetric plaque pH system at the University of Iowa. This system will be used for plaque pH evaluation during various food consumption patterns and for the evaluation of anti-glycolytic oral rinses. The study will be conducted in three phases. The first phase will consist of the in vitro development and testing of an fm-radiotelemetric plaque pH system. Initially, a recently commercially available fm transmitter will be adapted for use with a glass pH microelectrode. Two types of approaches will be taken. The first of these entails an entirely encapsulated version which will be designed to remain in the human volunteers oral cavity at all times. The second approach will allow use of the currently used indwelling wire-telemetric appliance adapted to connect the fm-transmitter when fm-telemetry is desired. The telemetric packages will be evaluated in buffer solutions for reliability, accuracy and average life-time expectancy. Following satisfactory performance, in Phase II the telemetric method will be applied for use in eight human volunteers. Volunteers will be selected using plaque pH screening methods to assume maximum plaque pH responses to fermentable carbohydrates. Each volunteer will carry out eight different test sessions consisting of between 8 and 24 hours of continuous plaque pH measurement. Each session will be designed to evaluate a particular food consumption pattern. Results will be analyzed and used to select food sequences that minimize acidogenic responses. Phase III will be conducted in limited numbers of volunteers to evaluate various anti-glycolytic oral rinses for their effect on long-term (12 hours) plaque pH responses. The development of this fm radiotelemetric method provides a significant improvement in the approach to evaluation of food consumption patterns through the use of human interproximal plaque pH measurement. It will be used to aid in the development of new recommendations and approaches to caries preventions.