CLINICAL HEART-LUNG AND LUNG TRANSPLANTATION

这一计划的总体目标包括发展和 心肺联合移植与单肺联合移植的研究 晚期心脏疾病患者的心脏移植 和/或肺，普通形式的治疗对他们没有帮助 有效康复的现实希望。特定的科学 目标包括：1)确定适当的标准 选择最有可能受益于这些形式的 2)供体器官移植方法的改进 采购和移植物保存(特别是肺脏)；3) 完善术中管理技术；4) 有效的术后免疫抑制方案的确定 并评价诊断排斥反应的新方法。 心肺和肺移植受者；5)前瞻性评估和 心肺病理与生理学的相关性分析 和肺移植；6)病理和遗传学研究 肺囊性纤维化患者特有的特征 疾病；7)体外研究病理生理特征和 大鼠肺动脉功能的药理学反应 体外循环或隔离手术患者的天然肺 肺移植。 此外，这项多学科的临床心肺计划 肺移植为医疗和医疗人员提供了深入的培训 外科实习生，并构成了一个关于 国家和国际两级。

The overall goal of this program consists of the development and study of combined heart-lung transplantation and single lung transplantation in patients with advanced disease of the heart and/or lungs for whom ordinary forms of treatment offer no realistic hope of effective rehabilitation. Specific scientific objectives include: 1) definition of appropriate criteria for the selection of recipients most likely to benefit from these forms of transplantation; 2) improvement of methods for donor organ procurement and graft preservation (specifically pulmonary); 3) refinement of techniques of intraoperative management; 4) definition of effective postoperative immunosuppressive regimens and evaluation of new methods for the diagnosis of rejection in heart-lung and lung recipients; 5) prospective evaluation and correlative analysis of the pathology and physiology of heart-lung and lung grafts; 6) investigation of pathological and genetic features specific to patients with cystic fibrosis pulmonary disease; and 7) in vitro study of pathophysiological features and pharmacological responses of pulmonary arterial function in the native lungs of patients undergoing cardiopulmonary or isolated pulmonary transplantation. In addition, this multidisciplinary program in clinical heart-lung and lung transplantation provides in-depth training to medical and surgical trainees and constitutes a demonstration project on national and international levels.