METABOLISM OF LIPOPROTEIN A IN HUMANS

Lp(A)是一种与风险增加密切相关的脂蛋白 过早的动脉粥样硬化性心血管疾病。一种蛋白质，它 鉴定这种独特的脂蛋白是apo(A)，它与 纤溶酶原。Apo(A)是多态的，具有许多不同的大小 种群中的蛋白质。这种体型多态是由基因决定的 确定的，并反过来是血浆水平的主要决定因素 Lp(A)。然而，其他因素也强烈影响Lp(A)水平，但 是非常不被理解的。我们已经确定，在有 相同的载脂蛋白(A)亚型，但Lp(A)水平大不相同，在 Lp(A)的产生率是血浆Lp(A)变化的原因 级别。这将人们的注意力引向了不同于 影响载脂蛋白(A)产生的载脂蛋白(A)亚型。 载脂蛋白(A)等蛋白大小对细胞密度影响的详细研究 Lp(A)表明apo(A)异构体越大，密度越大 Lp(A)粒子。两种形式的apo(A)的杂合子有两个截然不同的 Lp(A)的种群可以根据它们的 不同的密度。正在进行的研究主要集中在以下几个方面 载脂蛋白(A)的大小影响血浆Lp(A)水平。 这些研究对象的年龄在19岁到46岁之间。38%的 受试者为女性。这些研究包括一名亚洲受试者。

Lp(a) is a lipoprotein which is strongly associated with an increased risk of premature atherosclerotic cardiovascular disease. The protein which identifies this unique lipoprotein is apo(a), which has high homology with plasminogen. Apo(a) is polymorphic, with many different sizes of this protein in the population. This size polymorphism is genetically determined, and in turn, is a major determinant of the plasma level of Lp(a). However, other factors also strongly influence Lp(a) levels but are very poorly understood. We have established that in individuals with the same apo(a) isoform but widely different levels of Lp(a), variation in the production rate of Lp(a) is the cause of the variation in plasma Lp(a) levels. This directs attention to the genetic factors distinct from apo(a) isoform which affect apo(a) production. A detailed study of the effect of apo(a) isoprotein size on the density of Lp(a) demonstrated that the larger the apo(a) isoform, the more dense the Lp(a) particle. Heterozygotes for two forms of apo(a) have two distinct populations of Lp(a) that can be preparatively separated based on their different densities. Ongoing studies are focused on the mechanism by which the apo(a) isoprotein size influences plasma Lp(a) levels. These studies included subjects of age 19 to 46 years. 38% of the subjects were women. The studies included one Asian subject.