METABOLISM OF LP(A) IN HUMANS

Lp(A)是一种脂蛋白，与糖尿病的风险高度相关 过早的动脉粥样硬化性心血管疾病。一种蛋白质，它 鉴定这种独特的脂蛋白为apo(A)，具有很高的同源性 用纤溶酶原。Apo(A)是多态的，有许多不同大小的 这种蛋白质在种群中。这种体型多态是由基因决定的 确定的，并反过来是血浆水平的主要决定因素 Lp(A)。然而，其他因素也强烈影响Lp(A)水平，但 是非常不被理解的。放射性标记Lp(A)的体内代谢 在具有相同载脂蛋白(A)异构体的受试者组中测定 Lp(A)水平差异很大。Lp(A)的分解代谢率不是 在研究对象之间存在显著差异，而Lp(A)的产生 利率是非常不同的。因此，影响水平的一个主要因素是 除载脂蛋白(A)外，Lp(A)异构体似乎是 脂蛋白(A)脂蛋白。这对 对Lp(A)代谢的认识及临床处理 有高水平的Lp(A)和早发的冠心病。 这些研究对象的年龄在20岁到38岁之间。42%的 受试者为女性。这些研究包括一名非裔美国人和一名 亚洲受试者。

Lp(a) is a lipoprotein which is highly associated with risk of premature atherosclerotic cardiovascular disease. The protein which identifies this unique lipoprotein is apo(a), which has high homology with plasminogen. Apo(a) is polymorphic, with many different sizes of this protein in the population. This size polymorphism is genetically determined, and in turn, is a major determinant of the plasma level of Lp(a). However, other factors also strongly influence Lp(a) levels but are very poorly understood. The in vivo metabolism of radiolabeled Lp(a) was determined in groups of subjects with the same apo(a) isoform but widely different levels of Lp(a). The catabolic rates of Lp(a) were not significantly different among study subjects, whereas Lp(a) production rates were very different. Therefore, a major factor affecting levels of Lp(a) apart from apo(a) isoform appears to be the rate of production of the Lp(a) lipoprotein. This has important implications for the understanding of Lp(a) metabolism and the clinical approach to patients with high levels of Lp(a) and premature coronary heart disease. These studies included subjects of age 20 to 38 years. 42% of the subjects were women. The studies included one African-American and one Asian subjects.