NEUROTRAUMA CLINICAL RESEARCH CENTER

我们建议在加州大学建立一个神经创伤临床研究中心 迈阿密/杰克逊纪念医院医疗中心。该计划包括 临床和基础科学的五个项目，以及临床流行病学 和生物统计核心，其主要目标是创建一个全面的 病人登记；制定和实施预后指标 死亡率/发病率和结果；并为目前 以及未来的项目。这些项目的统一是因为他们对 创伤性中枢神经系统潜在的可治疗或可预防的病理机制 受伤。脑温在创伤后中枢神经系统调节中的作用 伤害是共同关注的一个特殊领域。计划范围包括：(A) 脑出血患者脑温变化的临床评价 重型急性颅脑损伤脑热疗的意义分析 与颅内压、脑脊液代谢产物和临床改变的关系 结果：(B)液压脑损伤后的海马区功能障碍 在大鼠体内，整合电生理、神经递质和 行为测量；(C)创伤后微血管分析 头部的完整性、血脑屏障和皮质回路功能- 损伤大鼠与脑温度变化的关系；(D) 损伤引起的急性星形细胞肿胀，主要集中在钙和 钙依赖激酶；和(E)中剂量的治疗作用 低温对实验性脊髓挫伤的治疗作用。我们的节目 依赖于若干独特和杰出的机构资源a)a) 拥有1485张床位的以大学为中心的主要医学中心 大德市绝大多数颅脑损伤和脊髓损伤病例 县，有200万人口；b)新改组的部门 流行病学和公共卫生学博士，在数据登记和 试验设计；以及c)在两个大脑中正在进行的主要研究计划 代谢/缺血性脑血管疾病和脊髓损伤， 提供多学科协作专业知识的广度和深度。

We propose a Neurotrauma Clinical Research Center at the University of Miami/Jackson Memorial Hospital Medical Center. The Program consists of five projects in clinical and basic science, and a Clinical Epidemiology and Biostatistics Core, whose primary aims are to create a comprehensive patient registry; to develop and implement prognostic indicators of mortality/morbidity and outcome; and to provide ongoing support to present and future projects. The Projects are unified by their concern with potentially treatable or preventable pathomechanisms of traumatic CNS injury. The role of brain temperature in modulating post-traumatic CNS injury is a particular area of common concern. Program areas include: (a) the clinical evaluation of altered brain temperature in patients with severe acute head injury, analyzing the significance of brain hyperthermia in relation to altered intracranial pressure, CSF metabolites, and clinical outcome; (b) hippocampal dysfunction following fluid-percussion head injury in the rat, integrating electrophysiological, neurotransmitter, and behavioral measures; (c) an analysis of post-traumatic microvascular integrity, blood-brain barrier, and cortical circuit function in the head- injured rat in relation to altered brain temperature; (d) mechanisms of injury-induced acute astrocytic swelling, with a focus on calcium and calcium-dependent kinases; and (e) the therapeutic role of moderate hypothermia in experimental contusive spinal cord injury. Our program relies upon several unique and outstanding institutional resources a) a 1485-bed university-centered major medical center which receives the overwhelming majority of head-injury and spinal cord-injury cases in Dade County, with its 2 million population; b) a newly restructured Department of Epidemiology and Public Health with expertise in data registries and trial design; and c) major ongoing research programs in both cerebral metabolism/ischemic cerebrovascular disease and in spinal cord injury, providing breadth and depth of multidisciplinary collaborative expertise.