SCOR IN CORONARY AND VASCULAR DISEASES

德克萨斯大学西南医学分校的缺血性心脏评分 达拉斯中心将继续进行旨在阐明 心肌缺血和再灌注期间的病理生理机制 进行性心肌梗死。该SCOR的研究工作建立在 从基本机制的阐述中得出的原则 对心肌缺血负责，其后果将有所改善 患者护理和康复，以及预防心肌梗死的能力 在一些人中有脑梗塞的危险。我们所做的实验研究 代表着生产性研究工作的继续， 在过去14年半的时间里一直在该计划内进行。 然而，临床科增加了4个新的研究科室 (项目2)我们的缺血性SCOR计划，包括将 阐明鱼油饮食降低糖尿病风险的机制 冠状动脉成形术后的再狭窄；研究将证明 5-羟色胺和血栓素是否在冠状动脉部位蓄积 损伤和狭窄在冠状动脉病变中具有重要的生理意义 血管阻力和血流；以及有助于发展核的研究 无创性的磁共振成像和波谱分析 检测心肌缺血并估计血流灌注，评估 节段性和全局性心功能，检测动脉粥样硬化 斑块。此外，还增加了新的研究，这些研究将 利用分子生物学方法：(A)评估缝隙连接蛋白 以及它们在调节细胞间通讯和钙离子中的作用 结合并确定它们与缺血细胞的功能是如何改变的 伤害(项目8)和(B)研究组织纤溶酶原之间的相互作用 激活剂及其内源性抑制物与突变组织的发育 可在相关动物模型中评估的纤溶酶原激活剂(和 后来的患者)他们的溶栓潜力(项目9)。一种新的 研究部分，将评估有助于 还增加了充血性心力衰竭的发展(项目10)。 我们还增加了新的研究来评估蛋白酶的作用。 在心肌细胞和血管损伤中的作用(项目7)，并研究 心肌缺血对心脏微循环的影响(项目4)。冠状动脉 心脏病仍然是当代西方国家的一大健康威胁 社会。这一缺血型SCOR计划卓有成效，并使其变得重要 对以下方面的贡献：(A)阐明基本病理生理学 参与细胞和血管损伤演变的机制 心肌缺血和梗死；(B)发展敏感 急性心肌缺血和心肌梗死的识别方法 并估计其程度；以及(C)提供更好的预后洞察 因此，选定的有可能患上未来缺血性心脏病的患者 并发症可能在发展之前就被识别出来。

The Ischemic Heart SCOR at The University of Texas Southwestern Medical Center at Dallas will continue research directed at elucidating pathophysiological mechanisms operative during myocardial ischemia and evolving myocardial infarction. Research work in this SCOR is built upon the principle that from the elucidation of fundamental mechanisms responsible for myocardial ischemia and its consequences will come improved patient care and rehabilitation, and the ability to prevent myocardial infarction in some individuals at risk. The experimental studies that we have proposed represent continuations of productive research efforts that have been ongoing within this Program during the previous 14-1/2 years. However, 4 new research sections have been added to the Clinical Section (Project 2) of our Ischemic SCOR Program, including new studies that will elucidate mechanisms responsible for fish oil diets reducing the risk of restenosis after coronary angioplasty; studies that will demonstrate whether serotonin and thromboxane accumulation at sites of coronary artery injury and stenosis are important physiologically in altering coronary vascular resistance and flow; and studies that will help develop nuclear magnetic resonance (NMR) imaging and spectroscopy for the noninvasive detection of myocardial ischemia and to estimate perfusion, evaluate segmental and global ventricular function, and detect atherosclerotic plaques. In addition, new research studies have been added that will utilize molecular biology methods to: (a) evaluate gap junction proteins and their role in the regulation of cell-to-cell communication and calcium binding and determine how their function is altered with ischemic cell injury (Project 8) and (b) study the interaction between tissue plasminogen activator and its endogenous inhibitor and develop mutant tissue plasminogen activators that may be evaluated in relevant animal models (and later patients) for their thrombolytic potential (Project 9). A new research section that will evaluate basic mechanisms contributing to the development of congestive heart failure has also been added (Project 10). We have also added new research studies to evaluate the role of proteases in myocyte and vascular injury (Project 7) and study the effects of myocardial ischemia on the cardiac microcirculation (Project 4). Coronary heart disease remains a major health hazard in contemporary western society. This Ischemic SCOR Program has been productive and made important contributions toward: (a) the elucidation of basic pathophysiologic mechanisms involved in the evolution of cellular and vascular damage during myocardial ischemia and infarction; (b) the development of sensitive methods for the identification of acute myocardial ischemia and infarction and estimating their extent; and (c) providing improved prognostic insight so that selected patients at risk for future ischemic heart disease complications may be identified prior to their development.