ALZHEIMER'S DISEASE CENTER CORE

在地球物理研究中所取得的许多科学进展 阿尔茨海默病(AD)的原因是既有井水可用 以AD患者和他们的组织为特征并共同努力 临床科学家和基础科学家之间的关系。大学里的AD研究 阿拉巴马州伯明翰分校就是在这种模式下培养出来的。在过去, 不同的科学学科通过该计划走到了一起 项目和R01格式来研究这种独特的人类疾病。这个 下一个被提议的是阿尔茨海默病中心核心(ADCC) 我们在这所大学研究AD的合乎逻辑的进展，因为它将 倍增研究机会，进一步凝聚学习力量 广告，并帮助招募新的调查人员，并加强 通过提供新的教育机会，了解与AD相关的问题。 拟议的ADCC由四个核心组成：行政、 临床、神经病理学和信息传递。行政部门 CORE将为规划和 执行所有旨在实现ADCC的活动 目标。在这个核心中，提供了特定的机制来监督 和监测ADCC的活动、质量保证、预算管理、 以及招募新的调查人员。后一个目标反映在 提交的试点项目，这些项目调查基础科学(即， 扣带皮质解剖；钠离子通道)和临床(口腔 沟通；能力)与广告相关的问题。临床核心意志 作为所有大学调查人员的资源，通过招聘和 每年对50名轻度痴呆的AD患者进行纵向评估 25名正常黑人受试者的招募和纵向评估 年。此外，该核心还将开始评估行为 在AD中发生的干扰以及帮助获得组织为 神经病理学核心，并提供患者档案管理和生物统计 服务。神经病理学核心还将作为 大学研究人员通过获取和提供中枢神经系统组织和 AD，正常的年长和年轻的人，提供关于 在临床核心中对患者进行跟踪，评估颞叶病理 在AD患者中，并作为解剖学和 免疫细胞化学技术。信息传输核心将提供 ADCC的教育部分，通过提供多种教育 为非专业公众和卫生专业人员举办的活动。具体地说， 黑人社区和家庭医生、内科医生和全科医生 都会成为目标。在UAB实施ADCC将进一步团结起来 我们的特定社区将把它的全部资源带到飞行中 来战胜这种叫做阿尔茨海默氏症的致命疾病。

Many of the scientific advances that have been made in the study of Alzheimer's Disease (AD) have been due to both the availability of well characterized AD patients and their tissue and to the collaborative efforts between clinical and basic scientists. The study of AD at the University of Alabama at Birmingham has been fostered on this model. In the past, disparate scientific disciplines have come together through the Program Project and R01 format to study this uniquely human illness. The Alzheimer's Disease Center Core (ADCC) which is proposed is the next logical progression for our study of AD at this University, as it would multiply the opportunities for research, further unite our efforts to study AD, and aid in the recruitment of new investigators, and enhance the visibility of AD related issues by allowing new educational opportunities. The ADCC, as proposed, is composed of four Cores: Administrative, Clinical, Neuropathology, and Information Transfer. The Administrative Core will provide the organizational base for the planning and implementation of all activities directed toward the fulfillment of ADCC goals. Within this Core, specific mechanisms are provided for overseeing and monitoring ADCC activities, quality assurance, budgetary management, and recruitment of new investigators. The latter goal is reflected in the submitted Pilot Projects, which investigate both basic science (i.e., cingulate cortex anatomy; sodium channels) and clinical (oral communication; competency) issues relevant to AD. The Clinical Core will serve as a resource for all University investigators by recruiting and longitudinally assessing 50 mildly demented AD patients per year and by the recruitment and longitudinal evaluation of 25 normal Black subjects per year. Additionally, this Core will also begin to assess the behavioral disturbances occurring in AD as well as help acquire tissue for the Neuropathology Core and provide patient file management and biostatistical services. The Neuropathology Core will also serve as a resource for University investigators by acquiring and making available CNS tissue and AD, normal older and younger individuals, providing specific diagnoses on patients followed in the Clinical Core, assessing temporal lobe pathology in AD patients, and serving as a resource unit for anatomical and immunocytochemical techniques. The Information Transfer Core will provide the educational component of the ADCC by providing multiple educational activities for the lay public and health professions. Specifically, the Black community and family practice, internists and general practitioners will be targeted. The implementation of an ADCC at UAB will further unite our specific community to bring to bear its full resources into the flight to conquer this devastating illness called Alzheimer's Disease.