PILOT STUDY--MYOCARDIAL RESPONSE TO HEMODYNAMIC STRESS IN AGING

沃伦·曼宁博士被选为职业生涯启动支持机构 由拟议的哈佛大学GRTC的研究发展核心 他的建议题为“心肌对血流动力学应激的反应” 曼宁博士正处于其职业发展的第一阶段 一名新成员加入医生科学家培训计划并 建议利用GRTC的支持来应用这些技术 到目前为止，他已经发育成熟了。这将导致提早进入 进入第二阶段，或者说他研究生涯中更独立的阶段 发展。因此，这种补充支助的目的是加强 这是他研究的主要方向。三年的工作是 勾勒出来，以阐明支撑时代的机制- 心脏肥厚反应对压力的相关下降 和音量过载。 曼宁博士将直接与首席调查员魏博士合作 哈佛大学GRTC，老年学代理主任 贝丝以色列医院和布里格姆妇女医院分部， 检验以下假设：(1)老年人的生活质量随年龄增长而变化 左心室肥厚反应的时间进程，(2) 肌球蛋白重链亚型的年龄相关性改变可能与 到个别心肌细胞优先死亡，表达 α重链异构体，(3)存在差异 老年心肌肥厚对雄激素的反应 心肌的反应。这项拟议的研究在Dr。 魏的实验室将由副教授珍妮·韦博士监督 哈佛医学院医学教授，他培养了一位 一系列以研究为导向的老年医生专注于 衰老的心血管方面。拟议的研究将支持 来自生物工程核心、生物统计学核心和 生理学核心。

Dr. Warren Manning has been selected for career initiation support by the Research Development Core of the proposed Harvard GRTC for his proposal entitled "Myocardial response to hemodynamic stress in aging". Dr. Manning is in Phase I of his career development as a new recruit into the Physician Scientist Training Program and proposes utilizing support from the GRTC to apply the techniques he has already developed to date. This will lead to an early entry into Phase II, or the more independent phase of his research career development. This supplementary support is thus aimed to enhance the primary direction of his research. Three years of work is outlined, to elucidate the mechanisms which underlay the age- associated decline in the cardiac hypertrophic response to pressure and volume overload. Dr. Manning will work directly with Dr. Wei, Principal Investigator of the Harvard GRTC, and Acting Director of the Gerontology Division of the Beth Israel and Brigham and Women's Hospitals, examining the hypotheses that (1) there is a change with age in the time course of the left ventricular hypertrophic response, (2) the age-dependent shift in myosin heavy chains isoforms may be related to preferential death of individual cardiocytes expressing the alpha heavy chain isoform, (3) that there is a differential response of the elderly myocardium of androgens on the hypertrophic response of the myocardium. The proposed studies, conducted in Dr. Wei's laboratory will be supervised by Dr. Jeanne Wei, Associate Professor of Medicine at Harvard Medical School who has trained a series of research oriented geriatricians focussed on cardiovascular aspects of aging. The proposed studies will support from the Bioengineering Core, the Biostatistics Core and the Physiology Cores.