FACILITY FOR NON-HUMAN PRIMATES IN INFECTIOUS DIS RES

该计划的目的是维持非人类灵长类动物， 生物危害防护设施中的其他小动物， 选择性呼吸道和肠道疾病。 另外很多 将对动物进行技术程序。 测试 各种流感病毒，人呼吸道合胞病毒 病毒和轮状病毒将在松鼠，猫头鹰，帕塔斯，恒河猴， 非洲绿色猴，可能还有雪貂。 呼吸道感染的研究将特别关注 候选疫苗株的测试，将涉及4至20 动物/研究。 个别研究可能不会超过两个月 每年将进行多达8项研究。 SEMA的技术和专业人员将执行 项目官员提供的实验方案。 这将 包括将灵长类动物与病毒材料一起接种， 项目官员，收集血液和组织样本， 身体检查和其他实验程序，如 剖腹探查术和淋巴结活检。 大部分 研究，预计SEMA将执行鼻和喉 拭子、气管灌洗、气管内接种、X光片和 临床观察。 对于典型的20只动物流感研究; 20 X光片，20例气管接种，600例鼻和咽拭子，120例 气管灌洗和100份血样将在28至56小时内进行， 日期间。

The objective of this program is to maintain non-human primates and other small animals in biohazard containment facilities for studies of selected respiratory tract and enteric disease. In addition, many technical procedures will be performed on the animals. Testing of various reassortant influenza viruses, human respiratory syncytial viruses and rotaviruses will be done in squirrel, owl, patas, rhesus, and African Green monkeys, and possibly ferrets. Studies with respiratory tract infections will, particularly, be focused on testing of candidate vaccine strains and will involve from 4 to 20 animals per study. Individual studies will likely not exceed two months in duration and up to 8 studies will be performed each year. The technical and professional staff of SEMA will perform the experimental protocols as provided by the Project Officer. This will include inoculating the primates with viral material provided by the Project Officer, collecting blood and tissue samples, performing physical examinations, and other experimental procedures such as exploratory laparotomies and lymph node biopsies. For most of the studies, it is anticipated that SEMA will perform nasal and throat swabs, tracheal lavages, intratracheal inoculations, radiographs and clinical observations. For a typical 20 animal influenza study; 20 radiographs, 20 tracheal inoculations, 600 nasal and throat swabs, 120 tracheal lavages and 100 blood samples will be performed over a 28 to 56 day period.