CARE AND HOUSING OF AIDS RESEARCH ANIMALS

该项目的目标是维持非人类灵长类动物在 用于研究各种生物危害的生物危害防护设施 剂. 此外，许多技术程序将在 110动物 这些生物制剂的测试将在恒河猴中进行， 非洲绿色猴，以及其他非洲、亚洲和新大陆物种 (i.e. talapoin和猪尾猴）。 关于Simian 免疫缺陷病毒（SIV）将侧重于滴定研究，病毒 从各种物种中分离，接种各种克隆， 病毒在动物间的传播。 据估计， 每年都会进行研究。 SEMA的技术和专业人员将执行 项目官员提供的实验方案。 这将 包括将灵长类动物与病毒材料一起接种， 项目官员，收集血液和组织样本， 身体检查和其他实验程序，如 剖腹探查术和淋巴结活检。 大部分 研究，预计SEMA将收集脊髓液，血清， 咽喉鼻拭子和粪便样本 接种应 静脉内、腹膜内、皮下进行， 肌肉注射

The objective of this Project is to maintain non-human primates in biohazard containment facilities for studies of various biological agents. In addition, many technical procedures will be performed on the 110 animals. Testing these biological agents will be done in rhesus, African green monkeys, and other African, Asian and New World species (i.e. talapoin and pigtail monkeys). Studies with Simian Immunodeficiency Virus (SIV) will be focused on titration studies, virus isolation from various species, inoculation of various clones and passage of virus from animal to animal. It is anticipated that several studies will be performed each year. The technical and professional staff of SEMA will perform the experimental protocols as provided by the Project Officer. This will include inoculating the primates with viral material provided by the Project Officer, collecting blood and tissues samples, performing physical examinations, and other experimental procedures such as exploratory laparomies and lymph node biopsies. For most of the studies, it is anticipated that SEMA will collect spinal fluid, sera, throat and nasal swabs and fecal samples. Inoculations shall be performed intravenously, intraperitoneally, subcutaneously and intramuscularly.