Defining a new player in atherosclerosis: The role of Adventitial Haemangioblasts as an "outside-in" driver of plaque growth and stability.

作为心脏病发作的根本原因，动脉粥样硬化是世界范围内导致死亡的主要原因。迫切需要新的治疗方法，这需要更好地了解动脉粥样硬化斑块是如何形成的。这个项目研究了我们在动脉外层发现的一组新的干细胞，以确定它们是如何导致斑块形成的，这样我们就可以开发针对这些干细胞的新疗法，以更有效地治疗动脉粥样硬化。

As the underlying cause of heart attack, atherosclerosis is a leading cause of death worldwide. New approaches to treatment are desperately needed and this requires a better understanding of how atherosclerotic plaques form in arteries. This project studies a new population of stem cells that we have discovered in the outer layer of arteries, to determine how they cause plaques to form, so that we can develop new therapies that target these stem cells to more effectively treat atherosclerosis.