Defining the requirements for effective immune responses

免疫系统对传染性病原体做出快速反应，以根除此类微生物，并限制它们对宿主造成的损害。患有初级免疫缺陷的人在其免疫系统细胞的发育和/或功能方面存在缺陷，更容易感染传染病。这项研究将对这些个体进行调查，以确定特定基因和免疫细胞的功能，以了解产生有效免疫反应的要求。

The immune system rapidly responds to infectious pathogens to eradicate such microbes and limit the damage they can inflict upon the host. Individuals with primary immunodeficiencies have defects in the development and/or function of the cells of their immune system and are more susceptible to infectious diseases. This study will investigate such individuals to identify functions for specific genes and immune cells in order to understand the requirements for generating effective immune responses.