CLINICAL HEART-LUNG AND LUNG TRANSPLANTATION

该计划的总体目标包括开发和 心肺联合移植与单肺移植的研究 晚期心脏病患者的移植 和/或肺，对于这些人来说，普通形式的治疗无法提供 切实有效的康复希望。 具体科学 目标包括：（1）确定适当的标准， 选择最有可能受益于这些形式的 移植; 2）改进供体器官的获取方法 采集和移植物保存（特别是肺）; 3） 完善术中管理技术; 4） 有效术后免疫抑制方案的定义 排斥反应诊断新方法的评价 心肺和肺受体; 5）前瞻性评价和 心肺病理生理相关性分析 6）病理学和遗传学研究 肺囊性纤维化患者的特征 疾病;和7）病理生理学特征的体外研究， 肺动脉功能的药理学反应 接受心肺或隔离手术的患者的自体肺 肺移植 此外，这一多学科计划在临床心肺 和肺移植提供了深入的培训， 外科实习生，并构成一个示范项目， 国家和国际层面。

The overall goal of this program consists of the development and study of combined heart-lung transplantation and single lung transplantation in patients with advanced disease of the heart and/or lungs for whom ordinary forms of treatment offer no realistic hope of effective rehabilitation. Specific scientific objectives include: 1) definition of appropriate criteria for the selection of recipients most likely to benefit from these forms of transplantation; 2) improvement of methods for donor organ procurement and graft preservation (specifically pulmonary); 3) refinement of techniques of intraoperative management; 4) definition of effective postoperative immunosuppressive regimens and evaluation of new methods for the diagnosis of rejection in heart-lung and lung recipients; 5) prospective evaluation and correlative analysis of the pathology and physiology of heart-lung and lung grafts; 6) investigation of pathological and genetic features specific to patients with cystic fibrosis pulmonary disease; and 7) in vitro study of pathophysiological features and pharmacological responses of pulmonary arterial function in the native lungs of patients undergoing cardiopulmonary or isolated pulmonary transplantation. In addition, this multidisciplinary program in clinical heart-lung and lung transplantation provides in-depth training to medical and surgical trainees and constitutes a demonstration project on national and international levels.