DUKE-VA CENTER FOR CEREBROVASCULAR RESEARCH

这项建议的目的是进行一项全面的研究 专注于脑血管疾病及其相关疾病的研究 后遗症。这些项目包括相关的临床和放射学 卒中高危患者的研究，药物动力学研究 抗血小板药物对脑缺血后毛细血管增殖的研究 多巴胺受体的研究和儿茶酚胺释放的研究 肾上腺髓质细胞。有几个研究神经元的项目 海马区的可塑性，去甲肾上腺素能神经元之一， 肾上腺素能和胆碱能受体，一种与空间恢复相关的受体 研究红藻氨酸后遗症的鼻中隔损伤后的行为 注射和一个研究enhaphalins和其他 神经递质在脑损伤后癫痫发作发展中的作用一个 最后一组项目集中在感觉皮层的神经功能上。 损伤初级传入通路后，细胞-细胞间的相互作用 关于培养神经元的膜生物化学。这些项目反映了一种 了解中风的一些实验方法，并将继续 强调了解术后功能恢复的生物学基础 卒中。

The objective of this proposal is to carry out a comprehensive research program focussed on the study of the cerebrovascular disease and its sequelae. The projects inlcude a correlative clinical and radiological study of patients at risk for stroke, a pharmacokinetic study of antiplatelet drugs, a study of capillary proliferation in ischemic brain, a study of dopamine receptors, and a study of catecholamine release from adrenal medullary cells. There are several projects studying neuronal plasticity in the hippocampus, one of noradrenergic neurons, one of adrenergic and cholinergic receptors, one correlating recovery of spatial behavior after septal lesions, one studying the sequelae of kainic acid injection and one studying the role of enhaphalins and other neurotransmitters in the development of seizures after brain injury. A final group of projects focusses on neuronal function of the senory cortex after injury to primary afferent pathways, on cell-cell interactions, and on the membrane biochemistry of cultured neurons. The projects reflect a number of experimental approaches to understanding stroke and continues to emphasize understanding the biological basis of recovery of function after stroke.