PILOT STUDY--MYOCARDIAL RESPONSE TO HEMODYNAMIC STRESS IN AGING

沃伦·曼宁博士被选为职业生涯启动支持 由拟议的哈佛GRTC的研究开发核心， 他的提案题为“心肌对血流动力学应激的反应 在老化”。 曼宁博士正处于职业发展的第一阶段， 医生科学家培训计划的新成员， 建议利用GRTC的支持来应用这些技术 他已经发展到今天。 这将导致提前进入 进入第二阶段，或者说他研究生涯中更独立的阶段 发展 因此，这一补充支助旨在加强 他研究的主要方向。 三年的工作 概述，以阐明的机制，使年龄- 心脏对压力的肥大反应下降 和容量过载。 博士曼宁将直接与首席研究员魏博士合作 他是哈佛GRTC的主任，老年学的代理主任， 贝斯以色列和布里格姆妇女医院分部， 研究假设：（1）随着年龄的增长， 左室肥厚反应的时间进程，（2） 肌球蛋白重链亚型的年龄依赖性转变可能与 导致表达 α重链同种型，（3）存在差异 雄激素对老年心肌肥厚的反应 心肌的反应。 拟议的研究，在博士进行。 Wei的实验室将由Jeanne Wei博士监督， 他是哈佛医学院的医学教授， 一系列面向研究的老年病学家专注于 老化的心血管方面。 拟议的研究将支持 从生物工程核心，生物统计核心和 生理学核心。

Dr. Warren Manning has been selected for career initiation support by the Research Development Core of the proposed Harvard GRTC for his proposal entitled "Myocardial response to hemodynamic stress in aging". Dr. Manning is in Phase I of his career development as a new recruit into the Physician Scientist Training Program and proposes utilizing support from the GRTC to apply the techniques he has already developed to date. This will lead to an early entry into Phase II, or the more independent phase of his research career development. This supplementary support is thus aimed to enhance the primary direction of his research. Three years of work is outlined, to elucidate the mechanisms which underlay the age- associated decline in the cardiac hypertrophic response to pressure and volume overload. Dr. Manning will work directly with Dr. Wei, Principal Investigator of the Harvard GRTC, and Acting Director of the Gerontology Division of the Beth Israel and Brigham and Women's Hospitals, examining the hypotheses that (1) there is a change with age in the time course of the left ventricular hypertrophic response, (2) the age-dependent shift in myosin heavy chains isoforms may be related to preferential death of individual cardiocytes expressing the alpha heavy chain isoform, (3) that there is a differential response of the elderly myocardium of androgens on the hypertrophic response of the myocardium. The proposed studies, conducted in Dr. Wei's laboratory will be supervised by Dr. Jeanne Wei, Associate Professor of Medicine at Harvard Medical School who has trained a series of research oriented geriatricians focussed on cardiovascular aspects of aging. The proposed studies will support from the Bioengineering Core, the Biostatistics Core and the Physiology Cores.