PILOT STUDY--HORMONAL REGULATION OF EXTRACELLULAR FLUID VOLUME IN THE OLD

芭芭拉·克拉克博士被选为职业生涯启动支持机构 研究发展核心咨询委员会的建议 “老年人细胞外液量的激素调节。” 克拉克博士是内科科学家培训计划的实习生 进入第二阶段，或独立调查的早期阶段 并与她的初选进行了一系列平行的调查 对肾脏钠排泄的生理学感兴趣。支持 老年心钠素拟进行两年药理研究 将扩大克拉克博士对肾脏生理学的系统检查 和衰老。 克拉克博士将继续与她的导师富兰克林博士合作 贝丝以色列医院的肾脏科主任爱泼斯坦正在检查 一种假设：1)衰老与脑细胞分泌的变化有关 ANP对容量刺激的反应，2)ANP的年龄相关性升高 衰老中的水平与终末器官肾和 血管阻力，3)随年龄增加的ANP水平可能是 导致基础血管加压素水平降低和衰老的原因是 与低钠血症的易感性增加有关。这个 拟议的研究，主要在贝丝以色列医院进行 临床研究中心将由富兰克林博士监督 爱泼斯坦，一位在国际上备受尊敬的肾病学者和 哈佛医学院医学教授。RIA，主题 征聘，生理学核心将是必要的组成部分 克拉克博士的研究资助。

Dr. Barbara Clark was selected for career initiation support by the Research Development Core Advisory Committee for her proposal "Hormonal Regulation of Extracellular Fluid Volume in the Old." Dr. Clark is a trainee in the Physician Scientist Training Program entering Phase II, or the early stage of independent investigation and has developed a parallel set of investigations to her primary interest in the physiology of renal sodium excretion. Support for the proposed two years of pharmacologic study of ANP in the elderly will broaden Dr. Clark's systematic examination of renal physiology and aging. Dr. Clark will continue to work with her mentor, Dr. Franklin Epstein, Chief of Nephrology at the Beth Israel Hospital, examining the hypothesis that 1) aging is associated with altered release of ANP in response to volume stimuli, 2) age-related elevation of ANP levels seen in aging are associated with end organ renal and vascular resistance, 3) elevated ANP levels seen with age may be responsible for lower basal vasopressin levels and 4) aging is associated with increased susceptibility for hyponatremia. The proposed studies, conducted largely in the Beth Israel Hospital Clinical Research Center will be supervised by Dr. Franklin Epstein, an internationally respected Academic Nephrologist and Professor of Medicine at Harvard Medical School. The RIA, Subject Recruitment, and the Physiology Cores will be necessary components of Dr. Clark's research support.