Defining steps in the molecular pathogenesis of lung cancer using immortalized human bronchial epithelial cells

肺癌仍然是全球癌症死亡的主要原因，它是由DNA异常引起的。这个项目旨在通过改变已知的癌症相关基因并研究它们在肺癌发展中的作用来加深我们对这种疾病的理解。该项目还旨在识别肺癌中的新基因，以及可以预测化疗药物反应的肿瘤表达谱。总而言之，这项研究将为治疗剂确定新的基因靶点。

Lung cancer remains the leading cause of cancer death worldwide and is caused by abnormalities in DNA. This project aims to further our understanding of this disease by altering known cancer-related genes and studying their effect on lung cancer development. This project also aims to identify novel genes in lung cancer as well as tumour expression profiles which can predict response to chemotherapy agents. In summary, this research will identify new gene targets for therapeutic agents.