CLINICAL RESEARCH CENTER

青少年肥胖是一个具有明显后遗症的问题 包括葡萄糖代谢改变和糖尿病易感性 糖尿病。 为了更好地了解与糖尿病相关的代谢异常 对于青少年肥胖，我们将比较葡萄糖和全身的比率， 病态肥胖和正常青少年中的蛋白质合成和代谢。 然而，通过限制卡路里来减轻体重是治疗肥胖的首选。 对于肥胖的青少年来说，生长迟缓的风险是一种不良的副作用。 因此，我们还将研究 不同条件下肥胖青少年蛋白质和葡萄糖代谢的变化 饮食条件。 由于过多的瘦体重是经常发生的 在肥胖青少年中， 饮食周期将基于通过测量确定的理想体重 全身的水分。 我们的研究应该澄清是脂肪还是碳水化合物 更适合的能量来源，以支持在肥胖的生长突增 接受低热量饮食治疗的青少年。 最后，我们将确定 如果肥胖青少年的体重减轻导致蛋白质正常化， 和葡萄糖代谢。

Adolescent obesity is a problem characterized by significant after-effects including altered metabolism of glucose and a predisposition to diabetes mellitus. In order to better understand the metabolic abnormalities associated with adolescent obesity, we will compare the rates of glucose and whole-body protein synthesis and catabolism in morbidly obese and normal adolescents. Whereas weight reduction by calorie restriction is the therapy of choice in obese adolescents, the risk of growth retardation is an undesirable side effect. Therefore, we will also investigate the relationship between the rates of protein turnover and glucose turnover in obese adolescents under different dietary conditions. Since excessive lean body mass is a frequent occurrence among obese adolescents, both the quantities of glucose and protein during the dietary periods will be based on ideal body weight determined by a measurement of total body water. Our studies should clarify whether fat or carbohydrate is the more appropriate source of energy for supporting the growth spurt in obese adolescents receiving hypocaloric dietary therapy. Finally, we will determine if weight reduction in obese adolescents results in a normalization of protein and glucose metabolism.