RADIONUCLIDE GENERATORS TO PRODUCE THE IRIDIUM-194 BETA EMITTER

该项目调查设计、制造、测试和 一种用于生物医学的新型放射性核素发生器 申请。这种发电机有很长的半衰期，很多 数年，并产生20小时的放射性核素子体 具有合适特性的高能β粒子 通过双功能络合物标记蛋白质。 在包含母核的194Os/194 Ir发生器中， 194O，半衰期为6.0年，有β衰变， Emax B=100keV，至19.15小时的194Ir女儿。1941年1月 子体衰变，释放出2.2 Mev的β粒子 基态为194个铂(86%)和328.5个keV 激发态，发射1.9 MeVβ粒子(9.2%)。 第一激发态为328.5 keV，发射能量为1.9 MeV β颗粒(9.2%)。有一束328.5 keV的伽马射线 以13%的绝对丰度追随194Ir的衰变。这个 194Ir衰变中没有高强度伽马射线， 328.5电子伏特的例外，使这个贝塔发射核 从剂量学的角度来看非常有吸引力 考虑因素。另一方面，328.5 keV的存在 伽马射线，使194Ir成为治疗肿瘤的高于90Y的核 成像。 初步计算表明，亲本的几个MCI， 20世纪40年代，可以在核反应堆中由双中子产生 捕捉到20世纪20年代的目标(自然丰度为41%)。通过 利用20世纪20年代的丰产，产量增加了两倍，结果和 也减少了杂质的产生。富有的人 浓缩倍数大于99%的Os-192是 从橡树岭国家实验室购买。

The project investigates the design, manufacturing, testing, and use of a novel radionuclide generator for biomedical applications. The generator has a long shelf-half-life, many years, and produces a 20 hour radionuclide daughter which emits high-energy beta particles that have suitable characteristics for labelling proteins through bifunctional chelates. In the 194Os/194 Ir generator containing the parent nuclei, 194Os, has a half-life of 6.0 years which beta-decays, EmaxB=100 keV, to the 19.15-hour 194Ir daughter. The 194Ir daughter decays with the emission of 2.2 Mev beta particles to the ground state of 194Pt (86%) and to the 328.5 keV first excited state with emission of 1.9 MeV beta particles (9.2%). There is a 328.5 keV first excited state with emission of 1.9 MeV beta particles (9.2%). There is a 328.5 keV gamma-ray which follows the decay of 194Ir with 13% absolute aboundance. The absence of high intensity gamma-rays in the decay of 194Ir, with the exception to the 328.5 keV, makes this beta emitter nuclei very attractive from the point of view of dosimetric considerations. On the other hand, the presence of 328.5 keV gamma-rays, makes 194Ir a superior nucleus to 90Y for tumor imaging. Preliminary calculations indicate that several mCi of the parent, 1940s, can be produced in a nuclear reactor by double neutron capture of an 1920s (natural aboundance of 41%) target. By using enriched 1920s, a two fold increase in the yield results and also reduces the production of impurities. The enriched Osmium-192 with enrichment factor of greater than 99% is purchased from Oak Ridge National Laboratory.