RADIONUCLIDE GENERATORS TO PRODUCE THE IRIDIUM-194 BETA EMITTER

该项目调查了设计、制造、测试和 将新型放射性核素发生器用于生物医学应用。 发生器具有长的货架半衰期，可使用多年， 一个20小时的放射性核素子体， 具有适于标记蛋白质的特性的颗粒 通过双功能螯合物。 在含有母核的194 - 0s/194-Ir发生器中， 0s，半衰期为6.0年，发生β衰变，EmaxB = 100 KeV， 19.15小时194-Ir的女儿 194-Ir子体衰变， 发射2.2 MeV的β粒子到基态194- Pt（86%）和328.5 KeV的第一激发态，发射 1.9 MeV β粒子（9.2%）。 有一个328.5KeV的第一次激发 发射1.9 MeV β粒子（9.2%）。 有一个 328.5 KeV γ射线，伴随着194-Ir的13%衰变 绝对丰富。 由于缺乏高强度的伽马射线， 194-Ir的衰变，除了328.5 KeV之外， 这种β发射体核非常有吸引力， 剂量学考虑。 另一方面， 328.5 KeV的伽马射线使194-Ir成为比90-Y更好的核， 肿瘤成像 初步计算表明母体的几毫希， 194 - 0s，可以在核反应堆中通过双中子产生 捕获192 - 0s（天然丰度为41%）目标。 通过使用 富集192 - 0s，产量结果增加两倍， 减少了杂质的产生。 浓缩的锇-192， 富集因子大于99%购自橡树岭 国家实验室。

The project investigates the design, manufacturing, testing, and use of a novel radionuclide generator for biomedical applications. The generator has a long shelf-half-life, many years, and produces a 20-hour radionuclide daughter which emits high-energy beta particles that have suitable characteristics for labelling proteins through bifunctional chelates. In the 194-0s/194-Ir generator containing the parent nuclei, 194- 0s, has a half-life of 6.0 years which beta-decays, EmaxB=100 KeV, to the 19.15-hour 194-Ir daughter. The 194-Ir daughter decays with the emission of 2.2 MeV beta particles to the ground state of 194- Pt (86%) and to the 328.5 KeV first excited state with emission of 1.9 MeV beta particles (9.2%). There is a 328.5 KeV first excited state with emission of 1.9 MeV beta particles (9.2%). There is a 328.5 KeV gamma-ray which follows the decay of 194-Ir with 13% absolute abundance. The absence of high intensity gamma-rays in the decay of 194-Ir, with the exception to the 328.5 KeV, makes this beta emitter nuclei very attractive from the point of view of dosimetric considerations. On the other hand, the presence of 328.5 KeV gamma-rays makes 194-Ir a superior nucleus to 90-Y for tumor imaging. Preliminary calculations indicate that several mCi of the parent, 194-0s, can be produced in a nuclear reactor by double neutron capture of an 192-0s (natural abundance of 41%) target. By using enriched 192-0s, a two-fold increase in the yield results and also reduces the production of impurities. The enriched Osmium-192 with enrichment factor of greater than 99% is purchased from Oak Ridge National Laboratory.