NEURAL AND HUMORAL CONTROLS OF GASTROINTESTINAL FUNCTION

核心A：行政核心 第一年建立的做法和程序将 持续期间内的 此外，执行委员会将收到并审查 申请新的试点项目。 外部审查委员会将 1985年9月，应执行委员会的要求召开了会议。 核心B：神经解剖学核心 将研究食管（负鼠）的肽能神经支配 使用新开发的协议。 定量方法将 介绍，使用新获得的超薄切片设备，研究 不同神经递质的绝对和相对神经节群 类型 分流束相关神经节和分流束 他们自己将被研究。 可行性研究将继续进行， 豚鼠和大鼠回肠梗阻模型。 考虑到 先前的研究已经证明了肠梗阻后平滑肌肥大， 阻塞，我们将询问是否以及在多大程度上肌间神经元 （包括它们的过程）反应。 他们的反应是否因 形态学和/或神经递质类型？ 将继续提供核心资源， 中心调查员。 核心C：动物核心 我们会改善电脑化存货系统，并继续与 研究人员根据他们的需要。 卡拉·克里斯滕森将在 接受培训，以满足DDCC研究者的潜在需求。 她将 处理DDCC库存，提供术后护理，特殊测量， 根据需要进食。

Core A: Administrative Core The practices and procedures established during this first year will be continued. In addition, the Executive Committee will receive and review applications for new pilot projects. The external review committee will be assembled at the request of the Executive Committee in September, 1985. Core B: Neuroanatomy Core The peptidergic innervation of the esophagus (opossum) will be investigated using the new protocols developed. Quantitative methods will be introduced, using newly acquired ultramicrotomy equipment, to study absolute and relative ganglionic populations of different neurotransmitter types. The shunt fascicle-related ganglia and the shunt fascicles themselves will be studied. Feasibility studies will be continued with the ileum obstruction model in guinea pig and rat. In view of the fact that the previous studies have demonstrated smooth muscle hypertrophy after gut obstruction, we will inquire whether and to what extent myenteric neurons (including their processes) react. Do their responses differ according to morphological and/or neurotransmitter type? Core resources will continue to be provided to facilitate projects of Core Center investigators. Core C: Animal Core We will refine the computerized inventory system and continue to work with investigators as required by their needs. Karla Christensen will be trained to meet the potential needs of the DDCC investigators. She will handle the DDCC inventory, provide post-op care, special measurements and feeding as required.