PURCHASE OF AN AMINO ACID ANALYZER AND SEQUENCER

南卡罗来纳大学将购买一种敏感的、高的 高性能氨基酸分析仪和氨基酸测序仪 来自生物医学研究的支持共享 仪器程序。这些工具将构成基础 作为一个核心设施，将向研究人员提供 校园里。化学系的七名调查人员和 生物学将在下列研究中主要使用这种设备： 葡萄糖与糖尿病相关蛋白相互作用机制的研究 自由基反应对蛋白质结构和衰老的影响； (B)胸苷酸合酶的活性部位环境，以及 用于癌症化疗药物的酶靶点 处理；(C)参与核DNA缩合的蛋白质 在精子发生和精子运动过程中；(D) 生物分子中的硒；(E)相互作用的分子基础 在导致靶细胞的人类补体蛋白之间 (F)碱性磷酸酶及其诱导物在 软骨中的矿化反应；(G)参与 光合作用细菌中的电子传递。此外，还有十二个 辅助用户将在各种情况下需要这些仪器 研究项目。 所要求的设备将代表着在 这所大学的生化研究仪器和 显著增强其支持现有和规划中的能力 研究项目。

The University of South Carolina will purchase a sensitive, high performance amino acid analyzer and amino acid sequencer with support from the Biomedical Research Support Shared Instrumentation Program. These instruments will form the basis for a core facility that will provide services to researchers on campus. Seven investigators in the Department of Chemistry and Biology will be major users of this equipment in studies of: (a) the mechanism of diabetes-related protein crosslinking by glucose and effects of free radical reactions on protein structure and aging; (b) the active site environment of thymidylate synthase, and enzyme target for chemotherapeutic agents used in cancer treatment; (c) proteins involved in nuclear DNA condensation during spermatogenesis and in sperm motility; (d) the role of selenium in biomolecules; (e) the molecular basis for interactions between human complement proteins that result in target cell death; (f) the role of alkaline phosphatase and its inducer in mineralization reactions in cartilage; (g) proteins involved in electron transport in photosynthetic bacteria. In addition, twelve auxiliary users will require these instruments in a variety of research projects. The requested equipment will represent a major improvement in biochemical research instrumentation at this University and significantly enhance its ability to support existing and planned research programs.