DISCOVERY OF GENES THAT PROTECT AGAINST TAU-INDUCED NEUROPATHOLOGY

痴呆症造成50亿澳元的直接医疗费用，影响30万澳大利亚人，其发病率正在上升。迫切需要新的治疗方法。痴呆症与大脑中的tau蛋白聚集体有关。发现预防tau聚集体引起的症状的基因将有助于开发新的治疗方法，但识别这些基因非常困难和昂贵。我们将利用我们世界领先的资源来彻底改变基因发现，并确定可以预防痴呆症的基因。

Dementia incurs $5 billion of direct health costs, affects 300,000 Australians and its incidence is increasing. New treatments are urgently needed. Dementia is associated with tau protein aggregates in the brain. Finding genes that prevent symptoms caused by tau aggregates will help develop new treatments, but identifying such genes has been very difficult and expensive. We will use our world-leading resource to revolutionize gene discovery and identify genes that can protect against dementia.