STUDIES OF THE NATURAL HISTORY AND TREATMENT OF DUCK HEPATITIS B VIRUS INFECTION

在结构和性能上有许多相似之处 人类乙肝病毒和鸭乙型肝炎病毒(D乙肝病毒)。 这使得鸭子感染D乙肝病毒成为一项非常有用的实验 人类乙肝病毒感染的模型，特别是由于乙肝病毒不能 在细胞培养中容易生长。鸭在出生时感染登革热病毒 成为病毒的慢性携带者，尽管他们可能不会 发展为显性肝炎。一些感染了D乙肝病毒的鸭子已经被 据报道发展为肝细胞癌，这是一种强烈的肿瘤 在病因学上与人类慢性乙肝感染有关。 新的抗病毒免疫调节剂正在评估中 它们抑制鸭乙型肝炎病毒复制的能力作为一种筛选 年对慢性乙型肝炎有效新疗法的试验 天哪。

There are many similarities in structure and properties between the human hepatitis B virus and duck hepatitis B virus (DHBV). This makes DHBV infection in ducks a very useful experimental model of human HBV infection, particularly as HBV cannot be grown readily in cell culture. Ducks infected with DHBV at birth become chronic carriers of the virus, although they may not develop overt hepatitis. Some DHBV-infected ducks have been reported to develop hepatocellular carcinoma, a tumor strongly linked etiologically in humans with chronic hepatitis B infection. New antiviral immunomodulatory agents are being assessed for their ability to suppress DHBV replication in ducks as a screening test for new effective therapies for chronic type B hepatitis in man.