CENTER FOR THE STUDY OF ALCOHOLISM

康涅狄格大学酒精研究中心致力于 遗传学、精神病理学、生物学和行为学的临床研究 多元背景下酒精中毒的各个方面。已有的变量 被选中进行调查的都与之前的理论有关 酒精中毒病因学的表述，以及哪些因素 在临床上被认为影响了疾病的自然病程 人群(以及高危人群) 无神论者)。通过多变量方法，我们希望开发出更多 准确界定重要概念，使临床治疗 对酗酒者的治疗效果可以得到改善，并评价疗效 变得更理性了。这些变量正在进行一系列的研究 平行及相关研究。酒精的研究计划 研究中心包括对选定的行为、 人口学、遗传学、精神病理学、生物学和大脑 各种相关研究中的认知功能变量与 临床人群。这项研究的首要目的是 考察这些变量与酒精依赖之间的关系 综合症。我们最初的一系列调查试图界定这些 以下背景下的变量：(1)对自然历史的研究 住院治疗后的酒精中毒(“类型学”研究)； 原发性和继发性情感性精神障碍的生物学和家系研究 对酒精中毒患者及其亲属的研究；(3)认知研究 酒精中毒患者进食和服药时的功能及脑电分析 12个月随访；(4)静脉注射乙醇的多因素研究 酒鬼寻酒行为的管理与刺激控制 患者和对照组；(5)尼古丁代谢的初步研究 酗酒和非酗酒吸烟者；和(6)家谱研究，包括 酗酒父母子女的遗传学和心理社会研究比较 与对照组(“前瞻性”研究)。拟议的研究旨在 对最初赠款中开发的一些有希望的线索的后续行动 句号。

The University of Connecticut Alcohol Research Center is dedicated to clinical studies of genetic, psychopathological, biological and behavioral aspects of alcoholism in a multivariate context. The variables that have been selected for investigation are related to previous theoretical formulations of the etiology of alcoholism, as well as those factors which are presumed to influence the natural history of the disorder in clinical populations (as well as individuals at high risk for developing acoholism). With a multivariate approach, we hope to develop a more precise definition of significant concepts, so that the clinical treatment of the alcoholic can be improved, and the evaluation of treatment efficacy made more rational. The variables are being explored in a series of parellel and interrelated studies. The research programs of the Alcohol Research Center involve a systematic examination of selected behavioral, demographic, genetic, psychopathological, biological, and brain and cognitive function variables in a variety of interrelated studies with clinical populations. The overriding purpose of this research is to examine the relationship between these variables and the alcohol dependence syndrome. Our initial series of investigations have sought to define these variables in the context of: (1) a study of the natural history of alcoholism subsequent to inpatient care (the "typology" study); (2) biological and pedigree studies of primary and secondary affective disorder in alcoholic patients and their relatives; (3) studies of cognitive function and the computerized EEG in alcoholic patients at intake and at 12-month follow-up; (4) multivariate studies of intravenous ethanol administration and stimulus control of drink-seeking behavior in alcoholic patients and controls; (5) pilot studies of nicotine metabolism in alcoholic and non-alcoholic smokers; and (6) pedigree studies, including genetic and psychosocial studies of offspring of alcoholic parents compared with controls (the "prospective" study). Proposed studies are designed to follow-up on a number of promising leads developed in the initial grant period.