REGENERATION & FUNCTIONAL RECOVERY IN NEURAL TISSUE

我们的总体目标是增加对因素的基本了解， 控制PNS和CNS神经纤维的生长和维持，以及存活 母神经元细胞体的结构，并更好地了解机制 参与了连接、适应和行为的发展 在中枢神经系统的不同区域的可塑性。 个别项目力求 研究：a）非神经元细胞分泌产物（可溶性和 不溶性），其促进CNS神经突生长和神经元存活。 动物和培养物，B）培养的CNS生长的再生潜力 在不同的环境条件下，以更好地了解 生长能力的差异，c）分布和分子关联 肌球蛋白、肌动蛋白和几种肌动蛋白相关蛋白在培养生长中的表达 锥体，以阐明负责神经元定向生长的机制 过程，d）通过以下改善神经修复后的功能恢复： 改善感觉神经元对损伤的反应， 神经生长因子的施用，e）突触递质的作用 在视觉皮层发育中，f）生理和形态基质 对于前庭眼反射的适应过程，g）反应 幸存的躯体感觉皮层接收的特性和联系 皮质病变在婴儿与成人的基础上寻找观察 h）小脑单位和纺锤体 传入放电，反射肌电图的变化和刚度和阻尼的 在防止由新负载产生的振荡期间的猴腕 通过自适应（可塑性）控制运动行为。 调查人员 在不同的实验范式和技术的专业知识，但分享 对神经突生长机制的研究有着强烈的共同兴趣 分析研究适应行为的最佳方法。 资金 要求以具有成本效益的方式支持共用设施（计算机 专业知识，电子显微镜和动物支持），并促进 参与者之间的互动和协作，以促进进展 为了更好地理解再生的基本机制， 和有用的可塑性。

Our overall goals are to increase fundamental knowledge of factors that govern PNS and CNS nerve fiber growth and maintenance, as well as survival of the parent neuronal cell body, and to better understand mechanisms involved in the development of connections and adaptation and behavioral plasticity in different areas of the CNS. The individual projects seek to investigate: a) nonneuronal cell secretory products (both soluble and insoluble) that promote CNS neurite growth and neuronal survival in the animal and in culture, b) regenerative potential of cultured CNS growth cones under differing environmental conditions to better understand differences in growth capacity, c) distribution and molecular associations of myosin, actin and several actin-associated proteins in cultured growth cones to clarify mechanisms responsible for oriented growth of neuronal processes, d) improving functional recovery following nerve repair by ameliorating the response of sensory neurons to injury with the administration of nerve growth factor, e) the role of synaptic transmitters in visual cortex development, f) physiological and morphological substrata for the process of adaptation of the vestibulo-ocular reflex, g) response properties and connections of surviving somatic sensory cortex receiving cortical lesions in infants vs. adults to search for the basis of observed behavioral recovery in the infant, and h) cerebellar unit and spindle afferent firing, reflex EMG changes and stiffness and damping of the monkey's wrist during prevention of oscillations produced by novel loads through adaptive (plastic) control of movement behavior. The investigators have expertise in diverse experimental paradigms and techniques, yet share strong common interests in pursuing study of mechanisms of neurite growth and analyzing ways in which to best investigate adaptive behavior. Funding is requested to support in a cost-effective way shared facilities (computer expertise, electron microscopy and animal support) and to foster interaction and collaboration among the participants to facilitate progress toward the goal of better understanding basic mechanisms of regeneration and useful plasticity.