DOCetaxel with or without radiation Therapy for resectable Oesophageal adenocarcinoma based on early PET Response to induction chemotherapy (DOCTOR).

尽管做了手术，食道癌的存活率仍然很低。对术前化疗有反应的患者比没有反应的患者有更好的存活率。这项研究建议使用早期FDG-PET扫描来识别对标准化疗无反应的患者。这将允许及时改变治疗方案，使用更新的药物，无论是否进行放射治疗，目的是改善结果。这代表着食道癌管理的范式转变。

Oesophageal cancer continues to have poor survival despite surgery. Patients responding to pre-operative chemotherapy have better survival than those who do not. This study proposes using early FDG-PET scan to identify patients not responding to standard chemotherapy. This will permit the timely change of therapy to alternative regimens with a newer agent with or without radiotherapy, aiming to improve outcomes. This represents a paradigm shift in the management of oesophageal cancer.