DIAGNOSTIC RADIOLOGY METHOD DEVELOPMENT RESEARCH

该计划的长期目标是开发新的诊断方法 方法学并将其应用于临床诊断放射学。一位少校 提案的一部分专门用于核磁共振成像，其中新的问题 随着新硬件的出现，研究机会正在快速打开 上线并有新的结果可用。光子辐射探测 技术也被探索，在所有重要的“前端” 技术一个新项目探索了在视觉上集成 由快速发展的诊断成像领域产生的信息。 具体地说，一种集成的核磁共振成像方法扩展到人类 大鼠的组织定征方案，以证实发现和 提供用于优化技术和以后启动的数据库 临床疗效研究。我们还建议研究实际问题。 核磁共振成像对磁场强度的依赖关系以及科学 核磁共振成像内源元素的能力问题 氢气。第三个方案探索了核磁共振技术在血液表征中的应用 在毛细管床中流动。各种技术已经证明 可行性，本项目从实用性和可操作性方面进行了探索 结果的有效性。并提出了潜在危害的研究方向。 尽管我们预计核磁共振是一种良性的性质，一种实用的方法 对于回答有关危险的问题，必须加以落实。这个 这样产生的信息将增加核磁共振的信心 应用于临床。这里提出的另外两个项目 源自现有的赠款资助活动，并代表投资于 已被证明卓有成效并将带来生产力的技术 在未来的应用中继续。这些交易中的第一笔与 锗探测器制作中的实际问题 用于成像设备。解决这些问题将为 极大地改善了核医学成像的可能性，并将 允许探索这些设备在其他诊断中的应用 区域。其中第二个项目探索了小说和 各种常见显示格式的信息，希望最大限度地 集成来自不同医疗设备的信息的可信度 由内科医生。

The long term goals of the Program are to develop new diagnostic methodologies and to apply them to clinical diagnostic radiology. A major portion of the proposal is dedicated to NMR imaging, where new questions and research opportunities are opening up at a fast pace as new hardware comes on line and new results become available. Photon radiation detection technologies are also explored, in the all important "front end" technology. A new project explores means of visually integrating the information produced by the rapidly advancing field of diagnostic imaging. Specifically, an integrated approach to NMR imaging extends to humans protocols of tissue characterization in rats, to corroborate findings and provide a data base with which to optimize the technique and later initiate clinical efficacy studies. We also propose to study the practical question of dependence of NMR imaging on magnetic field strength and the scientific question of NMR's ability to image endogenous elements other than hydrogen. A third proposal explores the use of NMR in characterizing blood flow in the capillary bed. Various techniques have demonstrated feasibility, and this project explores them in terms of practicality and validity of results. The study of potential hazards is also proposed. Although we expect NMR to be of a benign nature, a practical approach towards answering questions regarding hazards has to be implemented. The information thus produced will increase the confidence with which NMR can be brought into clinical practice. The other two projects proposed here derive from existing grant-funded activities and represent an investment in technologies that have proven fruitful and which will lead to productive continuation in future applications. The first of these deals with the practical problems encountered in the fabrication of germanium detectors for imaging devices. Solving these problems will open up the way for vastly improved nuclear medicine imaging possibilities, and will also permit exploration of application of these devices in other diagnostic areas. The second of these projects explores the integration of novel and varied information in common display formats, hoping to maximize the confidence with which the information from varied modalities is integrated by the physician.