NEURAL AND HUMORAL CONTROLS OF GASTROINTESTINAL FUNCTION

核心A：行政核心 在第一年建立的做法和程序将是 继续。此外，执行委员会将接受和审查 申请新的试点项目。外部审查委员会将是 应执行委员会的要求于1985年9月召开会议。 核心B：神经解剖学核心 本课程将研究食道(负鼠)的肽能神经支配。 使用开发的新协议。量化的方法将是 引进，使用新获得的超微切割设备，以研究 不同神经递质的绝对和相对神经节细胞群 类型。分流束相关神经节和分流束 他们自己也会被研究。我们会继续进行可行性研究。 豚鼠和大鼠回肠梗阻模型的建立。鉴于这一事实 先前的研究已经证明肠道后的平滑肌肥大。 梗阻时，我们将询问肌间神经元是否存在以及程度如何 (包括他们的进程)做出反应。他们的反应是否因 形态和/或神经递质类型？ 将继续提供核心资源，以促进核心项目 中心调查人员。 核心C：动物核心 我们将完善计算机化库存系统，并继续与 调查人员根据需要进行调查。卡拉·克里斯滕森将成为 接受培训，以满足DDCC调查人员的潜在需求。她会的 处理DDCC库存，提供术后护理、特殊测量和 按要求喂食。

Core A: Administrative Core The practices and procedures established during this first year will be continued. In addition, the Executive Committee will receive and review applications for new pilot projects. The external review committee will be assembled at the request of the Executive Committee in September, 1985. Core B: Neuroanatomy Core The peptidergic innervation of the esophagus (opossum) will be investigated using the new protocols developed. Quantitative methods will be introduced, using newly acquired ultramicrotomy equipment, to study absolute and relative ganglionic populations of different neurotransmitter types. The shunt fascicle-related ganglia and the shunt fascicles themselves will be studied. Feasibility studies will be continued with the ileum obstruction model in guinea pig and rat. In view of the fact that the previous studies have demonstrated smooth muscle hypertrophy after gut obstruction, we will inquire whether and to what extent myenteric neurons (including their processes) react. Do their responses differ according to morphological and/or neurotransmitter type? Core resources will continue to be provided to facilitate projects of Core Center investigators. Core C: Animal Core We will refine the computerized inventory system and continue to work with investigators as required by their needs. Karla Christensen will be trained to meet the potential needs of the DDCC investigators. She will handle the DDCC inventory, provide post-op care, special measurements and feeding as required.