Can Indoor Residual Spraying provide additional protection against clinical malaria over current best practice?

我们建议在西非的冈比亚进行一次大规模的实地试验，以查明除了让每个人都睡在浸有长效杀虫剂的蚊帐里的正常做法之外，用滴滴涕喷洒房屋是否有任何额外的好处。这项研究将包括两组村庄：一组只使用驱虫蚊帐，另一组既使用驱虫蚊帐又喷洒滴滴涕。我们将通过在两组村庄的房屋中采样蚊子和测量研究儿童的疟疾来衡量干预措施的有效性。重要的是，我们将确定病媒是否可能对所使用的杀虫剂产生抗药性，我们将能够确定使用滴滴涕预防疟疾病例的费用。这项研究很重要，因为包括冈比亚在内的许多非洲国家目前正在或打算在不久的将来向房屋喷洒滴滴涕。

We propose to carry out a large field trial in The Gambia, West Africa, to find out whether there is any additional benefit of spraying homes with DDT in addition to the normal practice of getting everyone to sleep under bednets impregnated with long-lasting insecticides. The study will have two groups of villages: one with only treated nets and the other with both treated nets and DDT spraying. We will measure how effective the interventions are by sampling mosquitoes in the houses and measuring malaria in study children in both sets of villages. Importantly we will determine whether the vectors are likely to become resistant to the insecticides used and we will be able to determine how much it will cost to prevent cases of malaria using the DDT. This study is important since many Afircan countries, including The Gambia, are either spraying houses with DDT at present or intend to do so in the near future.