Elucidating the role of JAM-B in breast cancer and angiogenesis

乳腺癌是英国女性中最常见的癌症，但血管生成如何在乳腺癌中受到调节尚不清楚。血管生长成肿瘤（血管生成）是肿瘤生长的必要条件，抗血管生成治疗是治疗癌症的重要新策略。有趣的是，患有唐氏综合症的女性很少会患上乳腺癌，这可能是由于21号染色体有三个副本。我们将确定21号染色体的三个拷贝如何抑制乳腺癌血管生成。我将重点讨论21号染色体中一种特殊的分子，称为JAM-B，我们已经有证据表明它在血管生成中起作用。我将同时使用临床材料和实验小鼠模型。这项研究将帮助我们更好地了解这种疾病，并可能导致抑制乳腺癌进展的治疗方法的发展。

Breast cancer is the most common cancer in women in the UK, but how angiogenesis is regulated in breast cancer is unknown. The growth of blood vessels into tumours (angiogenesis) is essential for cancer growth, and anti-angiogenic therapy is an important new strategy to treat cancer. Interestingly, women with Down Syndrome very rarely develop breast cancer, possibly as a result of the presence of three copies of chromosome 21. We will determine how three copies of chromosome 21 suppresses breast cancer angiogenesis. I will focus upon the involvement of a specific chromosome 21 molecule, termed JAM-B, which we already have evidence for a role in angiogenesis. I will use both clinical material and experimental mouse models. This research will help us to understand the disease better and possibly lead to the development of therapies to inhibit breast cancer progression.