Identifying Genetic Risk for Late-onset Alzheimer's Disease: The GERAD Consortium

阿尔茨海默病-S病(AD)是最常见的痴呆症，其人数将在下一代翻一番，仅在英国就有100多万患者。我们必须迅速了解阿尔茨海默病的病因，以便制定预防和治疗干预措施。我们有很好的证据表明，基因在阿尔茨海默病的发展中起着重要的作用，还有几个基因有待发现。这项研究将利用新的技术进步来测试每一个人类基因对患阿尔茨海默病风险的影响。这种方法的成功取决于使用非常大的AD病例和对照样本。这项研究是全球范围内最大的AD全基因组关联研究，预计将确定20个新的危险基因和疾病途径，AD风险基因精确定位触发疾病发展的主要生物学过程。

Alzheimer?s disease (AD) is the most common form of dementia whose numbers will double in the next generation resulting in over one million sufferers in the UK alone. It is vital we understand the causes of AD quickly to allow the development of preventative and therapeutic interventions. We have good evidence that genes play significant roles in AD development and that there are several remaining to be found. This research study will use new technological advances to test the influence of every human gene on the risk of developing AD. The success of this approach depends on using very large samples of AD cases and controls. This study is the largest genome-wide association study (GWAS) of AD world-wide and is anticipated to identify 20 new risk genes and disease pathways AD risk genes pinpoint primary biological processes which trigger disease development.