S Norris University of the Witwatersrand Health and wellbeing of female adolescents and young adults

撒哈拉以南非洲地区面临的一个主要挑战是孕产妇营养不良和产后发育迟缓与青少年和成年人肥胖风险增加之间的复杂关系，后者导致后代患2型糖尿病和代谢疾病的风险增加。对当代南非城市和农村青少年和年轻人（第1代）及其后代（第2代）的拟议研究将提供一个独特的机会，以评估与跨代传播的T2D和代谢性疾病风险因素相关的结果。主要研究问题涉及青少年体重增加的影响，T2D的妊娠风险和随后的后代疾病风险。

A major challenge in sub-Saharan Africa is the complex relationship between poor maternal nutrition and postnatal stunting on one hand and the increased risk of adolescent and adult obesity on the other leading to an increased risk of type-2 diabetes (T2D) and metabolic disease in future generations. The proposed studies of contemporary urban and rural South African adolescent and young adults (generation 1) and their offspring (generation 2) will provide a unique opportunity to evaluate outcomes relating to risk factors for T2D and metabolic disease that are transmistted across generations. Primary research question relates to the effects of adolescent weight gain, pregnancy risk for T2D, and subsequent offspring disease risk.