Top Jabs - Improving vaccination responses in older adults

老年人比年轻人更容易感染，这就是为什么NHS接种流感和肺炎疫苗是因为免疫系统老化。不幸的是，随着人们年龄的增长，他们的身体？S的免疫系统运行得不太好，这意味着对疫苗接种的反应更不能抵御疾病。重要的是要更好地了解为什么老年人的疫苗反应较差，并对其进行改善。我们计划在年长的动物和人类身上进行这方面的研究。我们将研究在小鼠身上制造高质量抗体的过程，并测试三种提高小鼠和人类接种反应的方法？添加疫苗成分；改善人们对胰岛素的敏感性？S；或者只是改变一天中接种疫苗的时间。

Older adults are more likely to get infections than young people, which is why the NHS vaccinates against the ?flu and pneumonia because of immune system ageing. Unfortunately, as people age, their body?s immune system works less well, meaning that responses to vaccination are less able to protect against illness. It is important to better understand why older people have poorer vaccine responses and to improve these. We plan to research this in older animals and humans. We will look at the processes involved in making high quality antibodies in mice, and test three ways of improving the vaccination response in mice and humans ? adding to vaccine components; improving people?s sensitivity to insulin; or simply changing the time of day when vaccines are given.