Desmoglein-2; an unsuspected regulator of melanoma

黑色素瘤是皮肤癌中最致命的一种，其患病率仍在上升。尽管取得了进展，但一旦转移，黑色素瘤几乎普遍是致命的。黑色素瘤的生长和扩散需要获得血液供应。血管生成拟态(VM)是一种新认识的过程，在这种过程中，癌细胞本身形成血管样结构，并导致转移和较差的生存。我们在控制肿瘤血管方面的工作可能会为抗击这种致命疾病提供新的选择。

Melanoma is the deadliest form of skin cancer which continues to rise in prevalence. Despite advances, once metastasized, melanoma is almost universally fatal. The growth and spread of melanoma requires access to the blood supply. Vasculogenic mimicry (VM) is a newly recognised process wherein the cancer cells themselves form vessel-like structures and contribute to metastasis and poor survival. Our work on controlling tumour vasculature may provide new options to combat this deadly disease.