Detection and manipulation of neuronal activities with a synthetic optogenetic activity-reporting transcription system

功能性脑映射对于理解抑郁症、注意力缺陷多动障碍和创伤后应激障碍等精神疾病非常重要。目前的脑功能图绘制技术是有限的，不适合大规模的研究。拟议的项目将产生新的工具，可用于绘制实验室模型生物体的激活神经回路，并将提高我们设计有效治疗精神疾病的能力。

Functional brain mapping is important for understanding mental illnesses such as depression, attention deficit hyperactivity disorders and post-traumatic stress disorders. Current techniques for functional brain mapping are limited and not suitable for large-scale studies. The proposed project will generate new tools that can be used to map activated neurocircuitry in laboratory model organisms and will enhance our ability to design effective treatments for mental illnesses.