TREATMENT OF MALIGNANT BRAIN TUMORS WITH INTERSTITIAL RADIOTHERAPY

目前大多数成人恶性脑瘤的治疗结果仍然存在 令人失望。尽管接受了最积极的多模式治疗，中位数 最常见的肿瘤是多形性胶质母细胞瘤，生存期为10个月。 而治愈则是轶事。这些肿瘤超出了外科手术的范围。 常规外照射的切除和总剂量是 受限于周围正常的大脑耐受性。通过将放射性物质 将碘125种子直接进入肿瘤床我们希望实现：1)a 对肿瘤的高辐射剂量；2)对周围的低辐射剂量 正常的大脑；3)放射治疗提高了治疗率 在低剂量率下。

Results of current therapy of most malignant adult brain tumors remain disappointing. Despite the most aggressive multimodality treatment, median survival in the most common tumor, glioblastoma multiforme, is 10 months and cure is anecdotal. These tumors extend beyond the limits of surgical resection and total dose of conventional external beam radiotherapy is limited by surrounding normal brain tolerance. By placing radioactive seeds of Iodine 125 directly into the tumor bed we hope to achieve: 1) a high radiation dose to the tumor; 2) a low radiation dose to surrounding normal brain; and 3) increased therapeutic ratio with radiation delivered at low dose rates.