ROLE OF THE ARTERIAL WALL IN ATHEROSCLEROSIS

该项目的主要目标是阐明（1） 高血压与脂蛋白在动脉粥样硬化发病机制中的作用; 平滑肌细胞和内皮细胞在血管通透性中的作用， 结缔组织蛋白的生物合成;（3）酸的作用 粘多糖和蛋白多糖与动脉粥样硬化及其相互关系 脂质、脂蛋白和钙在斑块中的沉积;（4） 血小板和血小板“释放作用”在动脉粥样硬化中的作用;（5） 脂质和脂蛋白在动脉粥样硬化中的理化变化;（6）作用 脂蛋白与酸性粘多糖、结缔组织 蛋白质和钙在动脉粥样硬化。 拟议的方案将得到执行 在实验性动脉粥样硬化的非人灵长类动物（食蟹猴）中 和/或高血压，并且在平滑肌细胞和内皮细胞中生长， 细胞培养 这些研究将集中在与生物化学， 动脉在发育过程中的代谢和形态变化， 治疗动脉粥样硬化和/或高血压血管疾病。

The major objectives of the project are to elucidate (1) the interactions of hypertension and lipoproteins in the pathogenesis of atherosclerosis; (2) the role of the smooth muscle cell and endothelial cell in vascular permeability and the biosynthesis of connective tissue proteins; (3) role of acid mucopolysaccharides and proteoglycans in atherosclerosis and their relationship to lipid, lipoprotein and calcium deposition in the plaque; (4) the role of platelets and the platelet "release action" in atherosclerosis; (5) role of physico-chemical changes of lipid and lipoproteins in atherosclerosis; (6) role of lipoprotein interactions with acid mucopolysaccharides, connective tissue proteins and calcium in atherosclerosis. The proposed programs will be carried out in subhuman primates (cynomolgus monkey) with experimental atherosclerosis and/or hypertension and in smooth muscle cells and endothelial cells grown in cell culture. These studies will focus on the correlations to the biochemical, metabolic and morphologic changes in the artery during the development and treatment of atherosclerotic and/or hypertensive vascular disease.