A/S SCOR: ARTERIOSCLEROSIS CENTER

这是HL-14237-10 SCOR：动脉硬化的继续应用 中心。计划继续并扩大目前的基础方案 和临床研究脂蛋白的结构和功能，与 始终强调结构、合成、分泌、相互作用 实验动物和大鼠血浆脂蛋白的细胞表面和分解代谢 模型系统。它还包括对收集的数据的详细分析 高脂蛋白血症的患病率和详细特征，新研究 论遗传因素和非遗传因素对结构和成分的影响 载脂蛋白与家族性糖尿病的治疗研究 高β-脂蛋白血症与药物治疗对载脂蛋白的影响 组成。 整个计划包括核心实验室和行政设施，以及 6个单独的研究项目：1)载脂蛋白在脂蛋白中的作用 分解代谢；2)富甘油三酯和高胆固醇脂蛋白的相互作用 血管表面的颗粒；3)脂蛋白和 载脂蛋白；4)正常和异常血浆的合成和分泌 脂蛋白；5)载脂蛋白的遗传和非遗传决定因素 脂蛋白的变异性；6)家族性高脂蛋白血症的治疗。

This is a continuation application for HL-14237-10 SCOR: Arteriosclerosis Center. It is planned to continue and extend the present program of fundamental and clinical research on the structure and function of lipoproteins, with emphasis throughout on the structure, synthesis, secretion, interaction with cell surfaces and catabolism of plasma lipoproteins in experimental animals and model systems. It also includes detailed analysis of data collected on the prevalence and detailed characterization of hyperlipoproteinemia, new research on genetic and non-genetic factors affecting the structure and composition of apolipoproteins and research on the treatment of familial hyperbetalipoproteinemia and the effect of drug treatment upon apolipoprotein composition. The total program includes core laboratories and administrative facilities and six individual research projects: 1) Role of apolipoproteins in lipoprotein catabolism; 2) Interactions of triglyceride- and cholesterol-rich lipoprotein particles with the vascular surface; 3) Structure of lipoproteins and apolipoproteins; 4) Synthesis and secretion of normal and abnormal plasma lipoproteins; 5) Genetic and non-genetic determinants of apolipoprotein variability in lipoproteins; 6) Treatment of familial hyperbetalipoproteinemia.