Mitochondrial dysfunction: Understanding how dysfunctional mitochondrial redox metabolism underpins pathology

线粒体氧化还原代谢对细胞的生死至关重要。因此，更好地了解其在健康和疾病期间的性质将导致对线粒体功能障碍如何成为病理基础的新见解，并促进新疗法的发展。线粒体功能障碍组专注于了解线粒体代谢和功能如何在生理和病理背景下结合起来改变氧化还原反应，如活性氧（ROS）和代谢物水平。这些变化随后被细胞的其余部分感知和解释，在某些情况下作为信号，在其他情况下作为病理的驱动因素。我们工作的一个重要方面是开发新的化学生物学探针和生物活性分子，以报告和操纵活生物体中的线粒体功能。我们还利用我们在线粒体功能障碍方面的知识来开发新的药物靶点和疗法。

Mitochondrial redox metabolism is central to the life and death of the cell. Consequently, a better understanding of its nature during health and disease will lead to new insights into how mitochondrial dysfunction underlies pathology and facilitate the development of novel therapies. The Mitochondrial Dysfunction group focusses on understanding how mitochondrial metabolism and function combine in physiological and pathological contexts to alter redox responses such as reactive oxygen species (ROS) and metabolite levels. These changes are then sensed and interpreted by the rest of the cell, in some cases as signals and in others as drivers of pathology. An important facet of our work is the development of novel chemical biology probes and bioactive molecules to report on and manipulate mitochondrial function in living organisms. We also leverage our knowledge of mitochondrial dysfunction to develop new drug targets and therapies.