Molecular drivers & predictors of pregnancy complications & future health

我们方案的目的是完成研究，以改善妇女及其婴儿在怀孕期间和产后期间的护理和健康。我们将解决的关键问题是：1)改进妊娠并发症的治疗，如妊娠期糖尿病和先兆子痫；2)确定妇女在怀孕前可能进行的治疗，如癫痫、抑郁症或哮喘的治疗，对她们的怀孕健康和婴儿健康的影响；3)改善产前护理，使监测针对不同妇女有健康怀孕或经历妊娠并发症的可能性；4)改善产后护理，确定哪些妇女应该在怀孕后评估糖尿病、心脏病和抑郁症等健康问题，以及何时应该看这些妇女，以及应该使用什么评估和治疗；5)了解有两种或两种以上慢性健康问题与妊娠并发症的关系。为了进行这项研究，我们将使用大型数据集，其中包括女性在怀孕前、怀孕期间和怀孕后的健康和行为信息，以及遗传和分子信息，如血液蛋白水平。我们将与产科医生、助产士、妇女和夫妇以及政策制定者合作，以确保我们的研究改善怀孕和出生后的健康。

The aim of our programme is to complete research that will improve the care and health of women and their babies as they go through pregnancy and into the postnatal period. The key issues that we will address are: 1) Improving the treatment of pregnancy complications such as gestational diabetes and pre-eclampsia; 2) Determining the effects of treatments that women might be on before they become pregnant, such as treatments for epilepsy, depression or asthma, on their pregnancy health and their babies health; 3) Improving antenatal care so that monitoring is tailored to differences between women in their likelihood of having a healthy pregnancy or experiencing a pregnancy complication; 4) Improving postnatal care by identifying which women should be assessed for health problems such as diabetes, heart disease and depression after pregnancy, and when these women should be seen and what assessments and treatments should be used; 5) Understanding the relationship between having two or more chronic health problems and pregnancy complications. To do this research we will use large datasets that include information on women’s health and behaviours before, during and after pregnancy as well as genetic and molecular information, such as blood protein levels. We will work with obstetricians, midwives, women and couples, and policy makers to make sure our research improves pregnancy and postnatal health.